Numerous 2009 reports of radiation leaks at multiple nuclear plants, including Pennsylvania's Three Mile Island, spawned even more sales of the radiation-blocking drug potassium iodide. Most online orders were from civilians not wanting to rely solely on the government for help in the event of a nuclear accident or terrorist attack. Many believe the slow process of evacuation would not alone protect them. National Public Radio (NPR) did a Thanksgiving Day feature story on Nukepills titled "Nuclear Radiation Worries? There's A Pill For That." This nationally broadcast NPR story raised additional awareness of the dire need for the stockpiling of potassium iodide in U.S. homes and dramatically boosted sales of the radiation drug.

Worries of a planned dirty bomb attack on New York City's transit system prompted orders of the Dirty Bomb Emergency Kit by civilians and heath officials in New York and other major cities. The kit includes the RADTriage Radiation Detector tested and approved by the U.S. Department of Homeland Security.

The 2009 Swine Flu pandemic unexpectedly boosted the bottom line for Nukepills as well. In response to media stories of the Swine Flu Virus (H1N1), the company's large inventory of N95 face masks, normally purchased online for protection during radiation decontamination, was depleted in just a few days. Nukepills quickly restocked and quadrupled its inventory of N95 masks to cover its wholesale and retail business for the remainder of the year. Again, those masks were quickly snatched up by hospitals, retirement homes and individuals to protect against the flu.