Lakshmi Prasad Dasi, PhD, former research engineer at Georgia Tech, now assistant professor of mechanical engineering at Colorado State University. James Fortenberry, MD, pediatrician in chief and medical director of critical care for Children's Healthcare of Atlanta, and clinical associate professor of pediatrics (critical care) at Emory School of Medicine Matthew Paden Ajit Yoganathan

The team's plan is to test their prototype in the laboratory and prepare for live experiments over the next two years, with the goal of being ready for clinical trials in five years.

"This is a project where we are taking technology from the laboratory bench to the basinet," Yoganathan says. "First, we have to build a machine capable of reliably performing these tasks without damaging blood cells in the process."

The team's prototype device is also designed to work in tandem with equipment that replaces the function of the heart and lungs for severely ill patients. Extracorporeal membrane oxygenation (ECMO) equipment is commonly used in neonatal intensive care units for newborns whose lungs can't work properly. Children requiring ECMO often have fluid overload and swelling. The demand for ECMO has been rising because of H1N1 influenza, which in severe cases leads to respiratory failure.

Emory, Georgia Tech and Children's Healthcare of Atlanta are in the process of patenting the kidney replacement device. As the technology is developed further, it could be licensed to an existing company or a new start-up company.

Source: Emory University